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VJHemOnc Podcast

Post-ASH AML highlights: novel approaches to frontline therapy, advances with menin inhibitors, & managing FLT3-ITD+ AML

Jan 31, 2025
Dive into the latest advancements in acute myeloid leukemia treatment showcased from the ASH Annual Meeting. Experts discuss innovative frontline therapies and the promising role of menin inhibitors in relapsed cases. Learn about the safety profiles and dosing strategies of Blexmenib, along with the efficacy of triplet therapies, particularly for FLT3-ITD+ patients. The conversation emphasizes the importance of continuous research to refine treatment options and improve outcomes for various patient demographics.
29:00

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Quick takeaways

  • Innovative approaches combining venetoclax with traditional chemotherapy regimens show high response rates and reduced toxicity in AML treatments.
  • Recent advancements in menin inhibitors, particularly their combination with other therapies, highlight improved response rates for relapsed acute leukemia.

Deep dives

Novel Chemotherapy Approaches in Acute Myeloid Leukemia

Innovative chemotherapy strategies were discussed, highlighting the combination of venetoclax with traditional induction chemotherapy regimens like 7 and 3. A phase 1b study showed that the addition of venetoclax did not significantly increase toxicity compared to 7 and 3 alone, which was reassuring for patient safety. Importantly, the study reported a high complete response (CR) rate of 85% across various cohorts, underscoring the efficacy of this regimen in achieving deep molecular responses. This finding suggests that single induction therapy may suffice for many patients, reducing the necessity for more intensive treatment options that contribute to higher toxicity levels.

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