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VJHemOnc Podcast

Updates on the use of BCMA-targeting bispecific antibodies in R/R multiple myeloma: insights from EHA & ASCO 2024

Jul 8, 2024
Guest Mohamad Mohty discusses updates on BCMA-targeting bispecific antibodies for multiple myeloma from EHA & ASCO 2024. Topics include MagnetisMM-3 trial data on elranatamab, real-world findings, step-up dosing of teclistamab, MAIC comparison of linvoseltamab with teclistamab, and sequencing of bispecific antibodies with CAR T-cells.
16:18

Episode guests

Podcast summary created with Snipd AI

Quick takeaways

  • Renatumab shows promising results in treating relapsed/refractory multiple myeloma, indicating a valuable salvage treatment option.
  • Utilizing step-up dosing for Teclistumab in real-world settings can optimize patient experience and reduce associated toxicities.

Deep dives

Renatumab Efficacy in Multiple Myeloma

Renatumab, a bispecific antibody targeting BCMA, shows promising results in Relapsed Refractory Multiple Myeloma. The Magnetism MM3 trial presented updated data, indicating an overall response rate of 60-65% and significant rates of complete response (CR) and very good partial response (VGPR). The median progression-free survival (PFS) reached around 17.5 months, with a median overall survival of 2 years. Results from both trial and compassionate use programs support Renatumab as a valuable salvage treatment, reinforcing its role in treating relapse refractory patients.

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