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VJHemOnc Podcast
An update on menin inhibition in AML from iwAL 2024: current data, mechanisms of resistance, & more!
Oct 23, 2024
Join experts Joshua Zeidner, MD from UNC Lineberger and Eunice Wang, MD from Roswell Park as they dive into the latest breakthroughs in menin inhibitors for acute myeloid leukemia (AML). They unravel how these inhibitors work against specific genetic mutations, offering hope in treating AML. The conversation covers exciting new data presented at the iwAL 2024, challenges in developing resistance, and the innovative combinations being explored to enhance efficacy. Get ready to learn about the future of targeted treatments in AML!
16:35
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Quick takeaways
- Menin inhibitors offer a promising targeted therapy for AML, especially in patients with KMT2A-rearranged and NPM1-mutated genetic profiles.
- The emergence of resistance to menin inhibitors highlights the need for innovative strategies and combination therapies to improve treatment outcomes.
Deep dives
Promise of Menin Inhibitors in AML Treatment
Menin inhibitors represent a promising new class of targeted therapies for acute myeloid leukemia (AML), particularly in patients with specific genetic mutations such as NPM1 and KMT2A rearrangements. Discussion highlighted the current exploration of four menin inhibitors, including Revumenin and Ziftomenin, which are being tested in patients with relapse refractory leukemia. The data presented indicated an encouraging clinical efficacy, with Revumenin showing a complete response rate of approximately 18% in heavily pretreated adults. These therapies are moving towards potential FDA approval as early as December this year, reflecting significant progress in the development of targeted treatments for AML.
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