Mast Cell Matters: Deep dives on MCAS with Tania Dempsey, MD - Presented by The POTScast Todd Maderis, ND on latest tests and treatments for underlying causes
Jul 7, 2025
Dr. Todd Maderis, a Naturopathic physician specializing in complex chronic illnesses, shares insights on advanced testing and treatments. He and Dr. Dempsey discuss the role of genetic testing and innovative therapies like SOT in tackling chronic infections. They dive into how excess fibrin might lead to coagulation issues and how environmental toxins affect health. Their conversation emphasizes personalized medicine and the importance of addressing root causes in patient care, offering hope for those facing chronic health challenges.
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Todd Maderis On Discovering MCAS
- Todd Maderis discovered MCAS after hearing Larry Afrin speak at ILADS and recognized the symptoms in his patients.
- He likens mast cells to a beehive being poked, emphasizing the importance of finding the root cause of activation.
Genetics Influence Mast Cell Reactivity
- Genetic predispositions, like variants in IL-13 and IL-4 genes, can increase mast cell reactivity by boosting IgE production.
- This explains why some patients have higher mast cell activity beyond environmental triggers.
Multi-Hit Model for Mast Cell Activation
- Multiple hits are often required for illness: genetic vulnerability plus early environmental exposures trigger mast cell activation.
- Chemical intolerance in mothers correlates with higher autism incidence, highlighting early mast cell impact.