BrainStuff How Does Psoriasis Work?
Nov 11, 2025
Psoriasis is a skin condition driven by an overactive immune system, often leading to discomfort and inflammation. It causes rapid skin cell turnover, resulting in flaky patches. The podcast dives into common symptoms, such as itching and pain, and explores genetic links that predispose some individuals to the disease. Various triggers can spark chronic flare-ups. Treatments range from topical therapies to advanced biologics, with ongoing research aiming to improve outcomes and understanding of this complex condition.
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Skin Renewal Runs Amok
- Psoriasis speeds skin replacement from ~4 weeks to about 4 days, causing buildup and plaques.
- This overdrive stems from an overactive immune response rather than an infection.
Genes Plus Triggers Cause Flares
- Genetics raise susceptibility but don't guarantee psoriasis; triggers matter too.
- Environmental events like injury, infections, weather, or stress often spark flares.
A Self-Sustaining Inflammatory Loop
- Researchers think a feedback loop between skin and immune system sustains inflammation.
- The loop brings extra blood flow and defensive cells without resolving anything.