Big Ideas Can science keep dementia at bay and keep your brain sharper − for longer?
Dec 4, 2025
Eleanor Drummond, a neuroscientist specializing in Alzheimer's research, joins Olivier Piguet, a clinical neuropsychologist focused on dementia interventions, and Gilbert Nags, a sociology PhD candidate exploring social inequalities in healthy ageing. They dive into how current science can combat cognitive decline, the role of lifestyle factors in brain health, and the risks posed by pseudoscience. Their discussion also highlights the importance of mapping protein changes in Alzheimer's and the need for diverse research trials. The duo provides insight into community challenges in rural ageing and the significance of intergenerational support.
AI Snips
Chapters
Transcript
Episode notes
From Biology To Behavioural Ageing
- Scientific focus has shifted from inner ageing mechanisms to external influences and behaviours.
- That shift expanded opportunities to age well but also increased anxiety and pressure to manage ageing choices.
Ageing Vs Disease In The Brain
- Normal brain ageing causes slower processing and reduced connections, not widespread neuron death.
- Dementia involves distinct pathology like protein clumping, inflammation and energy disruption that break down brain function.
Practical Lifestyle Steps To Lower Risk
- Adopt healthy habits: good diet, sleep, regular exercise, moderate alcohol, education and social engagement.
- These modifiable factors reduce population risk but individual risk still depends on genetics and life history.