OncoPharm A Brief History of Pemetrexed
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Jul 20, 2018 Explore the fascinating journey of pemetrexed, a drug that transformed non-small cell lung cancer treatment. Discover its roots in clinical trials starting in 1995 and the groundbreaking findings that emerged a decade later. The discussion highlights a pivotal 2008 study that ushered in histology-specific treatment approaches, illustrating how research can reshape medical practice. Tune in for insights into how these developments have influenced the lives of patients and the oncology landscape.
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Early Pemetrexed Dose Findings
- Early phase one pemetrexed studies established the maximum tolerated dose without vitamin supplementation.
- Neutropenia was the primary dose-limiting toxicity then, with dosing schedules evolving significantly.
Dexamethasone Prevents Rashes
- Administer dexamethasone around pemetrexed infusion to prevent skin rashes.
- Use 4 mg twice daily the day before, day of, and day after treatment.
Ensure Supplements with Pemetrexed
- Always confirm patients on pemetrexed take their folic acid and B12 supplements as scheduled.
- This practice prevents severe hematologic toxicity during therapy.