TWiV 1001: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses an update on vaccine-derived poliovirus outbreaks, how the dream of wiping out polio might need a rethink, risk of death in patients hospitalized for COVID-19 vs seasonal Influenza in fall-winter, French Mpox cluster includes fully vaccinated patients, two individuals with potential Mpox virus reinfection, epidemiologic and clinical features of Mpox-associated deaths, FDA authorizes changes to simplify use of bivalent mRNA COVID-19 vaccines, SARS-CoV-2 during Omicron variant predominance among infants born to people with SARS-CoV-2, severe maternal morbidity and mortality of pregnant patients with COVID-19 infection during the early pandemic period in the US, sickness presenteeism in healthcare workers during the COVID-19 pandemic, ventilation improvements among k–12 public school districts, risk factors and vectors for SARS-CoV-2 household transmission, SARS-CoV-2 neutralizing antibodies after bivalent versus monovalent, durability of bivalent boosters against Omicron subvariants, Nirmatrelvir and risk of hospital admission or death in adults with COVID-19, evolving real-world effectiveness of monoclonal antibodies for treatment of COVID-19, effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support–free days in patients hospitalized with COVID-19, efficacy and safety of Anakinra plus standard of care for patients with severe COVID-19, higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support, risk of autoimmune diseases in patients with COVID-19, definition of post–COVID-19 condition among published research studies, and sleep disturbance severity and correlates in post-acute sequelae of COVID-19. 

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Links for this episode

• Update on vaccine-derived poliovirus outbreaks (CDC)
• The dream of wiping out polio might need a rethink (NPR)
• Risk of death in patients hospitalized for COVID-19 vs influenza (JAME)
• French mpox cluster includes fully vaccinated patients (CIDRAP)
• Two individuals with potential Monkeypox reinfection (The Lancet)
• Epidemiologic and clinical features of Mpox-associated deaths (CDC)
• FDA authorizes changes to simplify use of Bivalent mRNA COVID-19 vaccines (FDA)
• Omicron variant predominance among infants born to people with SARS-CoV-2 (Pediatrics)
• Severe maternal morbidity and mortality of pregnant patients with COVID-19 (JAMA) 
• Sickness presenteeism in healthcare workers during the COVID-19 pandemic (ICHE)
• Ventilation improvements among K–12 public school districts (CDC)
• Risk factors and vectors for SARS-CoV-2 household transmission (The Lancet)
• SARS-CoV-2 neutralising antibodies after bivalent vs monovalent (The Lancet)
• Durability of bivalent boosters against Omicron subvariants (NEJM)
• Nirmatrelvir and risk of hospital admission or death in adults with COVID-19 (BMJ)
• Real world effectiveness of Monoclonal Antibodies for treatment of COVID-19 (AIM)
• Study on ACE inhibitor and ARB effect on COVID-19 patient outcomes (JAMA)
• Efficacy and safety of Anakinra plus standard of care for patients with severe COVID-19 (JAMA)
• High-dose corticosteroids in non-ventilated COVID-19 patients with hypoxia (The Lancet)
• Risk of autoimmune diseases in patients with COVID-19 (eClinical)
• Definition of post–COVID-19 condition (JAMA)
• Sleep disturbance severity and correlates in Post-acute Sequelae of COVID-19 (JGIM)
• Contribute to our ASTMH fundraiser at PWB
• Letters read on TWiV 1001
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv