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Neurology Minute
sNfL and Radiologic Disease Activity in Patients With MS - Part 1
May 1, 2024
Dr. Justin Abbatemarco and Dr. Bob Fox discuss serum neurofilament light chain as a marker for MS disease activity. They explore the challenges of interpreting these levels against normal protein turnover.
02:18
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Quick takeaways
- Serum neurofilament light can indicate neuronal health and disease activity in neurological conditions.
- Baseline turnover of neurofilament complicates its interpretation as an indicator of neuronal damage in diseased states.
Deep dives
Measurement of Serum Neurofilament Light and Its Role in Neurological Diseases
Serum neurofilament light, a protein family integral to neuron structure, offers insights into neurological conditions due to its stability in body fluids like blood. Its release from injured neurons is detectable in blood, providing a measurable indicator of neuronal health. Despite background levels in healthy individuals, deviations from baseline levels can signify disease activity, making it a valuable marker for assessing neurological conditions.
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