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VJHemOnc Podcast
Myeloma 2022: day two highlights
Sep 2, 2022
Gareth Morgan, Rafael Fonseca, Leif Bergsagel, and Keith Stewart discuss highlights from day two of the Myeloma 2022 meeting, covering topics such as BCL2 inhibitors, T-cell exhaustion, immunotherapy, targeted therapies, combination therapies, minimal residual disease, and the efficacy of Carti therapy in managing melon.
11:26
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Quick takeaways
- Understanding the biology and molecular mechanisms of BCL2 inhibitors, like nettoclax, is crucial for patient selection and predicting sensitivity to the drug.
- T-cell exhaustion is a key factor in resistance to immunotherapies, and strategies to overcome it, such as checkpoint inhibitors and limiting therapy duration, are important for improving efficacy.
Deep dives
Biology behind BCL2 inhibitors
One of the highlights discussed in the podcast was the biology behind the use of BCL2 inhibitors, specifically the drug nettoclax. The experts emphasized the importance of understanding the molecular mechanisms and patient selection for this drug. They mentioned the potential to predict sensitivity to nettoclax in the laboratory, particularly in patients with specific characteristics such as 1114 translocation. It was noted that nettoclax offers treatment options for patients in the early stages of disease and even in conditions like amyloidosis.
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