The News Meeting
Sensemaker: The malaria survivor who helped create a new vaccine
Jul 22, 2024
Mehreen Datoo, a malaria survivor, discusses the breakthrough in developing a new malaria vaccine, the challenges faced, and the potential impact on reducing malaria deaths worldwide. The podcast explores the personal account of malaria's impact, the efficacy of the R21 vaccine, and the need for further advancements in vaccine development for African communities.
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Quick takeaways
- The R21 malaria vaccine targets sporozoites to prevent liver cell infection, showing promising efficacy in trials.
- The vaccine, affordable and scalable, has the potential to significantly reduce malaria-related deaths in Africa.
Deep dives
Development of R21 Malaria Vaccine
The R21 malaria vaccine, developed by a team led by Maureen Dattu at Oxford's Jenner Institute, targets sporozoites transmitted by mosquitoes, preventing their infection of liver cells and halting the malaria life cycle. Initial trials showed promising results in UK adults, leading to phase one and phase two trials in malaria-endemic regions like Kenya and Burkina Faso. Subsequent trials in children in these areas demonstrated the vaccine's efficacy in protecting against malaria, sparking excitement and efforts to replicate the results in more countries.
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