The Curbsiders Internal Medicine Podcast REBOOT #151 Anaphylaxis
Mar 30, 2022
Recognize common presentations of anaphylaxis, diagnosing criteria, and treatment basics. Importance of epinephrine and utility of adjunctive therapies. Tips on counseling patients about auto-injectable epinephrine and a reminder not to panic. Overview of the podcast format and introduction to the guest speaker. Book recommendations, advice for fellows, and career goals. Discussion on biphasic reactions, predicting severity, and monitoring recommendations. Importance of educating patients on epinephrine usage.
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Recognizing Anaphylaxis
- Recognize anaphylaxis by considering mucocutaneous symptoms, like itching, and GI symptoms, like vomiting.
- These, along with a possible exposure, fulfill one diagnostic criteria, even without hypotension.
Anaphylaxis Pathophysiology
- IgE-mediated anaphylaxis involves allergen exposure, IgE binding, and mast cell activation, causing allergic symptoms.
- Non-IgE-mediated reactions activate mast cells without IgE, triggered by agents like vancomycin or contrast media.
First-Time Reactions
- A first-time reaction to a substance isn't IgE-mediated because sensitization requires prior exposure.
- Anaphylactoid reactions often respond to pre-medication, unlike IgE-mediated reactions.