Howie and Harlan are joined by Manisha Juthani, a Yale infectious disease specialist and commissioner of the Connecticut Department of Public Health. They discuss her research, including a study casting doubt on the use of cranberries to prevent urinary tract infection, and her priorities for Connecticut. Harlan reports on a wave of study retractions from the Dana-Farber Cancer Institute; Howie reflects on the progress made toward eradicating Guinea worm and malaria.