Overview of Gate BioScience and Molecular Gates

Gate BioScience is developing a new class of therapeutics called molecular gates that can eliminate disease-causing extracellular proteins. Extracellular proteins, which leave the cell and float around in the body or sit on the cell membrane, can cause various diseases. Gate's molecular gates bind to the secretory translocon, a channel that all extracellular proteins must go through, and block disease-causing proteins from passing through. This process redirects the protein back into the cell where it is recognized as mis-localized and degraded. Unlike injectable biologics, molecular gates are small molecules that can be taken orally, making them more convenient and enabling them to access tissues, including the brain, that are difficult for biologics to reach. By targeting extracellular proteins with small molecules, Gate offers new therapeutic possibilities for a wide range of diseases.