Core IM | Internal Medicine Podcast #179 Invasive Fungal Disease: 5 Pearls Segment
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Jun 11, 2025 Dive into the complexities of invasive fungal diseases and learn who’s at the highest risk for these infections. Discover the main classes of fungi and the diagnostic challenges with tests like beta-glucan and galactomannan. Uncover how to enhance blood culture yields and accurately interpret culture results. Explore treatment strategies and the implications of drug-drug interactions with antifungal medications. This episode sheds light on a critical area of infectious disease that is often overlooked.
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What Is Invasive Fungal Disease
- Invasive fungal disease occurs when fungi invade sterile tissues like bloodstream or deep tissue.
- It can range from localized invasion to widespread abscesses in multiple organs.
Key Risk Groups for Fungal Disease
- Major risk groups for invasive fungal disease include chemotherapy patients, abdominal surgery patients, and ICU patients with lines.
- Candida forms biofilms on lines that are nearly impossible to eradicate without line removal.
Consider Fungal Infection Beyond Classic Cases
- Always consider invasive fungal disease in immunocompromised patients even if not fitting classic categories.
- Anatomic abnormalities like bronchiectasis can predispose to invasive aspergillus infections.