The Intern At Work: Internal Medicine
224. An Uncontrollable Leak- The Approach to a VIPoma
Feb 11, 2024
Exploring the rare VIPoma tumor that causes watery diarrhea, with emphasis on diagnostic cues and clinical assessment. Discussing treatment options and the benefits of peptide receptor radionuclide therapy for improving survival rates.
11:13
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Quick takeaways
- Vipoma manifests as watery diarrhea, hypokalemia, and achlorhydria, requiring proper diagnosis to differentiate from similar conditions.
- Management of Vipoma involves surgical resection, somatostatin analogs, and advanced therapies for improved outcomes and symptom control.
Deep dives
Understanding Vipomas: An Overview
Vipomas, discovered in 1948 by scientists Werner and Morrison, are rare neuroendocrine tumors associated with hypersecretion of vasoactive intestinal peptide (VIP). These tumors commonly originate from pancreatic endocrine cells, causing a triad of symptoms including watery diarrhea, hypokalemia, and achlorhydria. Vipomas lead to excessive water and electrolyte secretion in the gastrointestinal system, resulting in significant fluid loss and electrolyte imbalances. Diagnosis includes assessing stool volume, electrolyte abnormalities, and conducting thorough physical exams to differentiate Vipoma symptoms from other similar conditions.
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