DarkHorse Podcast

Microbiomes and the World Within: Mark L. Cannon, DDS, MS on DarkHorse

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Sep 21, 2025
In a fascinating conversation, Dr. Mark L. Cannon, a Professor Emeritus focused on microbiomes, dives into the complex relationships between oral health and systemic diseases. He reveals how oral microbes influence conditions like Alzheimer's and diabetes, emphasizing the importance of microbiome balance. Dr. Cannon discusses innovative restoration strategies like probiotics and fecal transplants. With a metaphor comparing microbiomes to gardens, he advocates for preventative measures to nurture our internal ecosystems for better health.
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INSIGHT

Oral Microbiome As A Gateway

  • The oral microbiome is a key gateway influencing systemic immunity and health.
  • Disrupting oral symbionts with antimicrobials and diet surrenders protective functions to pathogens.
ADVICE

Use Xylitol Proactively

  • Use xylitol regularly (gum, toothpaste, mouthwash) to suppress pathogenic oral bacteria and support symbionts.
  • Start maternal xylitol use to reduce transmission and long-term dental disease in children.
INSIGHT

Oral Pathogens Drive Systemic Disease

  • Oral pathogens like Streptococcus mutans are linked to strokes, heart disease, Alzheimer's, and cancers.
  • Treating periodontal disease reduces systemic risk because pathogens can seed distant tissues.
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