The Critical Care Commute Podcast Sepsis Updated: Prof Mervyn Singer, Author of Sepsis 3.0
Sep 3, 2025
In this engaging discussion, Professor Mervyn Singer, author of Sepsis 3.0, shares his insights on the evolving treatment of sepsis. He addresses the crucial balance between antibiotics and steroids, emphasizing individualized care over rigid guidelines. The conversation highlights missed opportunities during the COVID-19 crisis and the complexities of managing the immune response in sepsis. Professor Singer also explores innovative strategies like metabolic interventions and the need for precision medicine, challenging traditional treatments for better patient outcomes.
AI Snips
Chapters
Transcript
Episode notes
Earlier Detection Lowers Initial Severity
- Sepsis severity has decreased because we recognise and treat it earlier and patients present sooner.
- The current challenge is supporting organ recovery after surviving the acute inflammatory phase.
Pauling As A Metaphor For Ideas
- Mervyn recalled Linus Pauling's mix of brilliant and eccentric ideas to illustrate many competing sepsis hypotheses.
- He used that to frame why many potential treatments (e.g., vitamin C) require careful testing.
Target Metabolism And Mitochondria
- Sepsis therapies must target different pathways: immune modulation, endothelium, and metabolism.
- Metabolic manipulation and mitochondrial protection are promising strategies to restart organ function.