Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler

For a TWiV Thanksgiving, Vincent, Alan, and Kathy trace the feud over genome editing, a new virus discovered in human blood, and the origins of hepatitis A virus.

Links for this episode

Battle over genome editing (Wired) 10:05
First description of CRISPR in E. coli (J Bacteriol) 14:00
Cas genes identified (Mol Micro) 14:20
CRISPR-Cas provides immunity to bacterial viruses (Science) 15:35
Cas9-crRNA complex mediates DNA cleavage (PNAS) 16:55
Dual RNA-guided DNA endonuclease in bacterial immunity (Science) 17:50
Genome engineering using CRISPR/Cas (Science) 18:50
Cpf1 endonuclease (Cell) 23:10
Classification of CRISPR/Cas systems (Nat Rev Micro) 23:50
Summit on gene editing 21:25
Novel human virus in transfusion recipients (mBio) 27:00
Origins of hepatitis A virus in small mammals (PNAS) 55:05
Image credit
Letters read on TWiV 365 7:00, 1:20:35

This episode is sponsored by ASM Microbe, ASM Biodefense, and the 32nd Clinical Virology Symposium. (1:10, 1:18:30)

Weekly Science Picks 1:36:30

Kathy - Tardigrade genome sequence (video)Alan - XKCD on Gates polio eradication site Vincent - Lifting the Impenetrable Veil by Charles Calisher

Listener Picks

Judi - Jennifer Doudna's Ted TalkRamon - Map of the Sky

Send your virology questions and comments to twiv@twiv.tv

TWiV 365: Blood, feuds, and a foodborne disease