The Incubator #308 - đź“‘ Journal Club - The Complete Episode from May 11th 2025
May 11, 2025
In a special anniversary edition, the hosts review fascinating neonatal studies. They discuss a trial on furosemide's safety for preterm infants and a compelling comparison of antibiotic courses for sepsis. The impact of sigh breaths on lung function during ventilation is explored, alongside the benefits of kangaroo care for boosting breast milk intake. They tackle prenatal cannabis exposure risks linked to low birth weight and delve into neurodevelopment outcomes for extremely preterm infants. The dialogue combines humor with crucial insights into neonatal care.
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Furosemide Safety in Preemies
- Furosemide is widely used in NICUs for preterm infants but lacks clear dosing and safety guidelines.
- A phase 2 trial found no significant increase in serious adverse events, hearing loss, or nephrocalcinosis with furosemide use.
Shorter Antibiotic Courses Effective
- Seven-day antibiotic courses may be as effective as 14-day courses for culture-proven neonatal sepsis in selected infants.
- This finding supports reducing antibiotic exposure safely in low- and middle-income settings.
Side Breaths Enhance Ventilation
- Adding intermittent sigh breaths during high-frequency oscillatory ventilation boosts lung volume and oxygenation in preterm infants.
- Larger trials are needed to assess safety and long-term benefits.