This is first part of the conversation with Randy Schekman. He is an  investigator of the Howard Hughes Medical Institute and a Professor of  Cell and Developmental Biology in the Department of Molecular and Cell  Biology at the University of California at Berkeley. He was awarded the Nobel Prize in Physiology or Medicine in 2013 for his  role in revealing the machinery that regulates the transport and  secretion of proteins in our cells. He shares the prize with James E.  Rothman of Yale University and Thomas C. Südhof of Stanford University. 

In this conversation we talk about his early career, membranes,  exosomes, scientific publishing and Elife journal. 

Listen to part II: https://youtu.be/MNjfkoutAhQ 

Find more about Randy's work: http://mcb.berkeley.edu/labs/schekman/ 

Randy's biography: https://www.nobelprize.org/prizes/medicine/2013/schekman/facts/ 

Episode links:

Website: https://www.reasonwithscience.com/home/the-noble-journey-with-randy-schekman-i

Youtube: https://youtu.be/bl1uG4PbTOE 

Spotify: 

Apple podcast:  

Google podcast:  

Follow Reason with Science:  

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Youtube: https://www.youtube.com/channel/reasonwithscience  

Spotify: https://open.spotify.com/show/5qFLGsPWjL4GAGidmF2nKh  

Apple podcast: https://podcasts.apple.com/us/podcast/reason-with-science/id1641776894  

Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw

Timestamps: 

00:00:00 Introduction 

00:01:08 Interest in microbes 

00:05:27 Yeasts have feelings too! 

00:06:24 What was already known about vesicular trafficking? 

00:08:42 How do you envision a cell?  

00:09:51 Your work to understand 'what is life'? 

00:12:48 Formation of membranes for the origin of life 

00:14:39 Why membranes are ideal for life! 

00:15:48 Differences of membranes  

00:17:07 The evolution of membranes 

00:19:02 Starting the work on vesicular trafficking 

00:23:09 Discovery of COPII complex 

00:25:24 The specialty of COPII complex  

00:26:30 Importance of vesicular trafficking for animal physiology 

00:27:39 Understanding of gut feeling! 

00:28:56 What has changed after Nobel prize? 

00:30:30 Different cellular trafficking system 

00:32:11 Exosomes and miR223  

00:34:29 Problems with exosomes as therapeutics 

00:35:08 Peer-review and scientific publishing 

00:39:44 Genesis of Elife  

00:44:05 Impact factor of Elife 

00:46:35 Thank you!  

More Talks from Randy: 

TEDx on scientific publishing: https://youtu.be/-N4Mb8tsyT8 

iBiology: https://youtu.be/xvjUgTKlKyU 

Nobel prize inspiration initiative lecture: https://youtu.be/Udg6bYkBtX8  

#reasonwithscience #nobelprize #cellbiology