The Intern At Work: Internal Medicine
221. Red Pulp, White Pulp - An approach to splenomegaly
Jan 21, 2024
Dr. Gizelle Popradi, a hematologist, and Dr. Samuel Mamane, a general internist, discuss the physiology, etiology, and treatment of splenomegaly. They cover topics such as different causes of splenomegaly, diagnostic approaches, treatment options including chemotherapy and surgical interventions, and the importance of identifying underlying causes for appropriate management.
12:14
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Quick takeaways
- Splenomegaly can have diverse etiologies including infectious, neoplastic, and inflammatory causes.
- Spleen evaluation involves clinical exams and diagnostic workup including imaging studies and laboratory tests for proper treatment planning.
Deep dives
Overview of Spleen Function and Composition
The spleen is the largest lymphatic organ in the human body, situated in the posterior left upper quadrant of the abdomen near the stomach, colon, and left kidney. Comprising red pulp and white pulp components, it plays crucial roles in hematologic functions, such as filtering and storing platelets, and immunologic responses involving lymphocytes and macrophages.
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