High Intensity Health with Mike Mutzel, MS
Higher LDL-Cholesterol Tied to Lower Risk of Death
May 15, 2024
A study challenges low LDL cholesterol benefits; optimal range is higher than expected. U-shaped curve of high LDL and mortality risk. Focus on cholesterol ratios and triglycerides. Importance of advanced health markers for longevity.
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Quick takeaways
- Low LDL cholesterol linked to higher cardiovascular mortality risk; optimal range is 100-189 mg/dL.
- Total cholesterol to HDL ratio crucial for assessing cardiovascular risk; mid-range LDL levels show lowest risk.
Deep dives
Low LDL Cholesterol Linked with Higher Cardiovascular Mortality
A 22-year follow-up study involving 177,000 individuals revealed that lower levels of LDL cholesterol were associated with an increased risk of dying from cardiovascular-specific mortality. Contrary to common belief that lower LDL levels are better, the study found that individuals with LDL levels between 160-190 milligrams per deciliter had the highest survival probability. This challenges the conventional wisdom of aggressively lowering LDL cholesterol, emphasizing the need to consider other factors like inflammation, blood viscosity, and insulin resistance in assessing cardiovascular health.
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