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The Carlat Psychiatry Podcast

Ketamine: Six New Findings Part 2

Nov 13, 2023
New research on ketamine explores its efficacy compared to ECT and antipsychotics, placebo effects, and the effectiveness of ketamine versus esketamine. The podcast also discusses sustaining the benefits of ketamine, incorporating psychotherapy, and using subliminal messages during treatment. Additionally, conflicts of interest in a psychotherapy study and the belief of weight gain on lithium are analyzed in this informative episode.
19:47

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Quick takeaways

  • Ketamine generally has larger effect sizes compared to esketamine, but direct head-to-head comparisons have shown both treatments to be equally effective.
  • To sustain the benefits of ketamine or esketamine, long-term maintenance therapy is usually recommended, and combining psychotherapy with ketamine treatment can enhance its effectiveness.

Deep dives

Effectiveness Comparison: Ketamine vs. Eskeetamine

Ketamine and eskeetamine are two drugs used in the treatment of depression, but their effectiveness is still a topic of debate. Animal studies suggest that the R ketamine may have stronger antidepressant effects, while clinical data from meta-analyses indicate that ketamine generally has larger effect sizes compared to eskeetamine. However, direct head-to-head comparisons have shown both treatments to be equally effective. Ketamine requires IV delivery, while eskeetamine is more expensive and only available as a brand-only product.

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