I've Got Questions with Sinead Bovell Brain Scientist On AI: You Aren’t Ready For What’s About To Happen | Dr. Alysson Muotri
Nov 27, 2025
Dr. Alysson Muotri, a leading geneticist and neuroscientist, dives into the groundbreaking world of brain organoids. He shares insights on how these mini-brains could revolutionize our understanding of neurological diseases and even influence AI development. Topics include organoids as personalized disease avatars, the ethical ramifications of merging biology with computation, and the potential for organoid intelligence to navigate complex tasks. Muotri’s work opens fascinating doors to the future of medicine and artificial intelligence.
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Organoids Unlock The Hidden Brain
- Brain organoids recreate early human brain development cell-by-cell, offering access we never had before.
- This access explains why neurological diseases remain largely incurable and opens paths to new treatments.
Self-Assembling Mini-Brains From Stem Cells
- Pluripotent stem cells can be guided to self-assemble into 3D neural tissues that fire and form microcircuits.
- After initial cues the cells follow genetic programs to build complex neural networks over months.
Vascularization Is The Scaling Bottleneck
- Current organoids reach ~0.5 cm and millions of cells but lack vascularization, limiting growth and longevity.
- Achieving vascularization is the key step to scale organoids toward adult-like complexity.