Episode 64 Navigating the Ketogenic Landscape with Dr. Dominic D'Agostino

Unlock the secrets of the ketogenic diet with Dr. Dominic D'Agostino as we navigate the nuances of ketogenic protocols, from their clinical roots in epilepsy treatment to their modern-day applications in enhancing athletic prowess and brain health. Whether you're a seasoned keto aficionado or simply curious about this high-fat lifestyle, you're in for a wealth of knowledge that could reshape your understanding of nutrition.

Timeline (Episode 64)

1:50 Dr. Dom has cows and gators in his backyard! His dogs have fought with gators. The mammals win! 

3:45 Definition of Ketogenic Diet (KD)

8:18 There are over 100 years of clinical use of the KD

9:04 Fasting was a “cure” for seizures

11:00 Effects on the brain – how does the KD affect normal healthy subjects

15:10 Dom has been a KD for 15 years

18:34 Dom used the old MET-Rx brand way back when!

21:00 Exogenous ketone ester supplementation studies – where do we stand on this?

21:58 Consume MCT oil (the poor man’s ketone ester)

26:30 Higher ketone levels is not better

27:00 Ketone esters > Ketone salts in extreme environments

28:00 Dosing of Ketone esters (higher is not better)

29:22 Don’t exceed 10 grams of Beta-hydroxybutyrate

34:07 Advantage of being in ketosis vis a vis performance – under conditions of glycogen depletion esp. in the cognitive domain

41:57 A good supplement to start with are MCT oils (since it will elevate your ketones)

45:20 Perhaps use these esters as a training aid; given acute may enhance PVT

49:30 Debunking the myth that high fat diets are always “bad.”

About our guest: Dominic D’Agostino

• Ph.D., Physiology, Neuroscience, University of Medicine and Dentistry of New Jersey, 2004
• B.S., Biological Sciences, Nutrition Science, Rutgers University, 1998

A researcher and professor with a diverse background in neuroscience, molecular pharmacology, nutrition, and physiology, Dominic D’Agostino, Ph.D., is a tenured Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida (USF) Morsani College of Medicine. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC). Dr. D’Agostino earned his Ph.D. in 2004 and subsequently entered into a postdoctoral fellowship in neuroscience at the Boonshoft School of Medicine at Wright State University in Ohio.

He has been awarded numerous grants that have resulted in national and international research collaborations and publications in such peer-reviewed journals as the Journal of Applied Physiology, Cell Metabolism, Neuroscience, Carcinogenesis, Nature Medicine, Journal of Neurophysiology, and the Journal of Microscopy.

About the Show

We cover all things related to sports science, nutrition, and performance. The Sports Science Dudes represent the opinions of the hosts and guests and are not the official opinions of the International Society of Sports Nutrition (ISSN), the Society for Sports Neuroscience, or Nova Southeastern University. The advice provided on this show should not be construed as medical advice and is purely an educational forum.

Hosted by Jose Antonio, PhD

Dr. Antonio is the co-founder and CEO of the International Society of Sports Nutrition and the co-founder of the Society for Sports Neuroscience, www.issn.net. Dr. Antonio has over 120 peer-reviewed publications and 16 books. He is a Professor at Nova Southeastern University, Davie, Florida in the Department of Health and Human Performance.

Twitter: @JoseAntonioPhD

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Co-host Anthony Ricci EdD

Dr Ricci is an expert on Fight Sports and is currently an Assistant Professor at Nova Southeastern University in Davie Florida in the Department of Health and Human Performance.

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