Trial of the Week: DESIRE & In-Flight Medical Emergencies References

Special Guests: Jim Miller, PharmD, BCCCP @millerjtm

Michael Liu, PharmD, MBA, BCCCP, BCNSP, BCPS

04:05 – DESIRE trial

31:15 – In-flight medical emergencies

The episode starts off with special guest, Jim Miller, helping review the DESIRE study as a Trial of the Week.

We set the scene reviewing dexmedetomidine pharmacokinetic advantages and landmark dexmedetomidine research. Then we highlight the DESIRE trial itself discussing the study methodology and results. What was considered usual care with regards to sedation? What is the external validity in this trial? What was the effect of changing the primary outcome measure mid-study? Are there anti-inflammatory properties with dexmedetomidine? What did Jim’s novel research show? What would Jim and I want for sedation if mechanically ventilated? And much more.

Then the episode closes with Michael Liu highlighting his experience assisting with an in-flight medical emergency.

We review his AJHP article describing his experience. Was this his first time in this situation? Biggest difference between in-hospital and out-of-hospital emergency response? What advice would he give others? And so much more.

Reference list: https://pharmacytodose.files.wordpress.com/2024/05/desire-trial-of-the-week-references.pdf

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