Freely Filtered, a NephJC Podcast

Freely Filtered 022: Uric Acid faces the Music.

Jul 28, 2020

01:15:58

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Highlights

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Episode notes

Is There a Gene Variant That Explains Uric Acid Level?

01:48

How Do You Know if You Have High Urate Level?

01:48

I Think the Sent in Oxides Is Is Quite Bad. And I Think It's Definitely Seems to Be Quite Bad

01:53

Introduction

5min

Dosage of Aloperinal in Paul and Skaty Fix

4min

The Primary Outcomes of L Perne and C K D Fix L Penicibo

3min

The Contrast Nephropathy, Is It a Diabetic Kidney Disease?

2min

Diabetic Dialysis

2min

G F I's Greater Than 60, They're Awful.

3min

Is There a Drug Interaction Between Urate and Urate?

5min

Is Ala Purena Just for Gout?

3min

Allerpirinon

3min

10.

The Effect of Aloperinon on G F R

2min

11.

What's Your Take on the Albu Minuria?

3min

12.

The Cost of Alopirinel

2min

13.

The Cost of Clinical Trials

2min

14.

The Effects of Alpune on Blood Pressure

4min

15.

I've Been Doing That for Many Years, I'm Complicating It Also.

3min

16.

Do You Know if You're a Diabetic?

5min

17.

Mendalian Randomization

2min

18.

Uric Acid, a Genovide Association Analysis

2min

19.

How Do You Know if You Have High Urate Level?

2min

20.

Is There a Gene Variant That Explains Uric Acid Level?

2min

21.

Mandilian Renal Physiology

3min

22.

Riht O, That Iatin Sho Up Today.

2min

23.

I Think the Sent in Oxides Is Is Quite Bad. And I Think It's Definitely Seems to Be Quite Bad

2min

24.

Nephrology Isn't Doing Enough Randomised Control Trials

3min

25.

Are Peepy Eyes Bad for Coved?

3min

26.

Covet and the Cowboy

4min

27.

In Shock by Arona Adishe

3min

The Filtrate:

Joel Topf

Swapnil Hiremath

Samira Farouk

And special guests:

Katalin Susztak, Professor of Medicine Perlman School of Medicine, University of Pennsylvania. @KSusztak

Show Notes:

CKD-FIX: Effects of Allopurinol on the Progression of Chronic Kidney Disease

PERL: Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes

Coverage at NephJC: Effects of Allopurinol on the Progression of Chronic Kidney Disease

Richard Johnson’s theory in pay-walled Nature Reviews Nephrology: Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome

Richard Johnson’s theory in open access Nehrology Dialysis and Transplantation: Uric acid and chronic kidney disease: which is chasing which?

PERL: Preventing early renal loss

Iohexol, good for measuring GFR as well as causing contrast associated nephropathy?

Uric acid versus urate: The Crystallization of Monosodium Urate

Association of HLA-B*5801 allele and allopurinol-induced Stevens Johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis

WHO list of essential medications

Fixing the numbers, specifically phosphorous

GFR Decline as an End Point for Clinical Trials in CKD: A Scientific Workshop Sponsored by the National Kidney Foundation and the US Food and Drug Administration

Cost of allopurinol: $7/month but it is only $9 for 3 months

Febuxostat Therapy for Patients With Stage 3 CKD and Asymptomatic Hyperuricemia: A Randomized Trial

Tipping point analysis - multiple imputation for stress test under missing not at random (MNAR) or a YouTube video if that’s your speed (sorry, I couldn’t find a TikTok on imputation stress tests).

Mendelian randomization study of urate and CKD by Ron Do and team

Dad jokes

Fake systematic review by Johnson’s group showing Urate lowering prevented CKD

Hyperuricemia As a trigger of Immune Response in Hypertension and Chronic Kidney Disease by Claudio Ponticelli published the week after these two RCTs were published.

NEJM Editorial: Urate-Lowering Therapy and Chronic Kidney Disease Progression by Daniel Feig

COVID and PPI manuscript

Hashtag the cowboy

‘WhatsApp®’ening in nephrology training

Arkana LIVE Pathology Sessions

NephJC Summer Book Club. Read Rana Awdish’s In Shock

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