Cardionerds: A Cardiology Podcast
410. Case Report: A Curious Case of Refractory Ventricular Tachycardia – Rutgers-Robert Wood Johnson
Episode guests
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Quick takeaways
- The case highlights the critical importance of thorough evaluation and rapid intervention in patients experiencing refractory ventricular tachycardia due to complex medical histories.
- Advanced imaging techniques, like cardiac MRI, play a vital role in accurately diagnosing hypertrophic cardiomyopathy and determining appropriate management strategies.
Deep dives
Heart Failure Management and Clinical Guidelines
Heart failure guideline-directed medical therapy (GDMT) is crucial for improving patient outcomes, yet many healthcare providers still fail to implement recommended treatments. Vital to addressing this issue is a collaborative approach among cardiology experts who advocate for adherence to these clinical guidelines so patients receive optimal care. The call to action emphasizes the necessity of educating both practitioners and patients about the principles of GDMT to stimulate effective management of heart failure. By raising awareness of this gap, stakeholders aim to enhance the quality of cardiovascular care on a global scale.
Case Presentation of Cardiac Arrest Patient
The podcast features the challenging case of a 61-year-old man who suffered an out-of-hospital cardiac arrest, emphasizing the importance of rapid and effective intervention. Upon examination, he was found to have multiple medical conditions, and CPR was administered at home before EMS transferred him to the hospital. Despite unclear information regarding the rhythm at the time of cardiac arrest, the focus shifted to potential causes that might have led to his condition, such as acute ischemia and electrolyte abnormalities. This highlights the need for thorough evaluation and history taking to better understand and manage complex clinical scenarios.
Management of Ventricular Tachycardia
In dealing with the patient’s recurrent episodes of pulseless polymorphic ventricular tachycardia (VT), the clinical team faced a dire situation that required prompt decision-making regarding treatment options. Initial management included administering antiarrhythmic medications such as lidocaine and magnesium, while also considering further diagnostics like cardiac catheterization to rule out ischemia. This underscores the nuanced approach required for effectively treating patients experiencing electrical storms, where both pharmacological interventions and potential device therapy should be meticulously evaluated. The discussion reveals the continuous balancing act between maintaining hemodynamic stability and effectively addressing life-threatening arrhythmias.
Advanced Imaging and Hypertrophic Cardiomyopathy
Cardiac MRI revealed that the patient had hypertrophic cardiomyopathy (HCM) characterized by asymmetric basal septal hypertrophy without late gadolinium enhancement, suggesting a lower arrhythmic risk. Despite a frightening presentation with recurrent VT, the absence of late gadolinium enhancement indicates a potentially non-obstructive subtype of HCM, which carries a generally favorable prognosis. The case emphasizes the importance of advanced imaging techniques in accurately diagnosing conditions that can manifest through severe arrhythmias like polymorphic VT. This insight not only aids in crafting targeted management strategies but also raises awareness about the need for diligent screening of family members for genetic predispositions to HCM.
CardioNerds (Dr. Colin Blumenthal and Dr. Saahil Jumkhawala) join Dr. Rohan Ganti, Dr. Nikita Mishra, and Dr. Jorge Naranjo from the Rutgers – Robert Wood Johnson program for a college basketball game, as the buzz around campus is high. They discuss the following case involving a patient with ventricular tachycardia:
The case involves a 61-year-old man with a medical history of hypothyroidism, hypertension, hyperlipidemia, seizure disorder on anti-epileptic medications, and major depressive disorder, who presented to the ER following an out-of-hospital cardiac arrest. During hospitalization, he experienced refractory polymorphic ventricular tachycardia (VT), requiring 18 defibrillation shocks. Further evaluation revealed non-obstructive hypertrophic cardiomyopathy (HCM). We review the initial management of electrical storm, special ECG considerations, diagnostic approaches once ischemia has been excluded, medications implicated in polymorphic VT, the role of multi-modality imaging in diagnosing hypertrophic cardiomyopathy, and risk stratification for implantable cardioverter-defibrillator (ICD) placement in patients with HCM.
Expert commentary is provided by Dr. Sabahat Bokhari. Episode audio was edited by CardioNerds Intern and student Dr. Pacey Wetstein.
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Pearls – A Curious Case of Refractory Ventricular Tachycardia – Rutgers-Robert Wood Johnson
- Diagnostic Uncertainty in VT Storm: In VT storm, ischemia is a primary consideration; when coronary angiography excludes significant epicardial disease, alternative causes such as cardiomyopathies, channelopathies, myocarditis, electrolyte disturbances, or drug-induced arrhythmias must be explored.
- ST elevations in ECG lead aVR: ST elevations in lead aVR and diffuse ST depressions can sometimes represent post-arrest oxygen demand and myocardial mismatch rather than an acute coronary syndrome. This pattern may occur in the context of polymorphic VT (PMVT), where myocardial oxygen demands outstrip supply, especially after an arrest. While these ECG changes could suggest myocardial ischemia, caution is needed, as they might not always indicate coronary pathology. However, PMVT generally should raise suspicion for underlying coronary disease and may warrant a coronary angiogram for further evaluation.
- Medication Implications in PMVT and HCM: Certain medications, including psychotropic drugs (e.g., antidepressants, antipsychotics) and anti-epileptic drugs, can prolong the QT interval or interact with other drugs, thereby increasing the risk of polymorphic VT in patients with underlying conditions like HCM. Careful management of these medications is critical to avoid arrhythmic events in predisposed individuals.
- Multi-Modality Imaging in HCM: Cardiac MRI with late gadolinium enhancement (LGE) is invaluable in assessing myocardial fibrosis, a key predictor of arrhythmic risk, and can guide decisions regarding ICD implantation. Echocardiography and contrast-enhanced CT can provide additional insights into structural abnormalities and risk assessment.
- Polymorphic VT in Nonobstructive HCM: Polymorphic ventricular tachycardia (PMVT) can occur in nonobstructive hypertrophic cardiomyopathy due to myocardial fibrosis and disarray, even in the absence of significant late gadolinium enhancement and left ventricular outflow tract obstruction.
- ICD Risk Stratification in HCM: Risk stratification for ICD placement in HCM includes assessment of clinical features such as family history of sudden cardiac death, history of unexplained syncope, presence of nonsustained VT on ambulatory monitoring, massive left ventricular hypertrophy (wall thickness ≥30 mm), and evidence of extensive myocardial fibrosis on cardiac MRI.
Notes – A Curious Case of Refractory Ventricular Tachycardia – Rutgers-Robert Wood Johnson
- Is there a benefit of starting antiarrhythmic medications for patients presenting with an out-of-hospital cardiac arrest with shock-refractory VT or VF?
- There is likely no benefit. An RCT published by Kudenchuk et al in 2016 in which patients who had a non-traumatic out-of-hospital cardiac arrest with shock-refractory VF or pulseless VT were randomly assigned to receive lidocaine, amiodarone, or saline placebo, in addition to standard care, showed that neither antiarrhythmic drug had a significantly higher rate of survival or favorable neurologic outcome compared to placebo6.
- What is the differential diagnosis and empiric management for a patient with polymorphic ventricular tachycardia?
- The differential diagnosis for ventricular tachycardia includes myocardial ischemia, electrolyte derangements, medications that may cause QT prolongation, congenital long QT syndrome, Brugada syndrome, myocarditis, dilated cardiomyopathy, arrhythmic cardiomyopathies, and infiltrative or structural heart disease.
- Standard BLS and ACLS measures are first-line treatment for pulseless VT.
- For stable patients, the 2017 AHA/ACC/HRS0 guidelines list beta-blockers as first-line antiarrhythmic therapy because they have been shown to reduce mortality and suppress ventricular arrhythmias in structurally normal hearts3. Amiodarone is also listed, though its long-term effect on survival is unclear, with most studies showing no clear benefit over placebo 3. Lidocaine and mexiletine are also commonly used, but because they are less efficacious compared to amiodarone, they are usually used as combination therapy for refractory patients4. Multiple trials have demonstrated the efficacy of procainamide as an adjunct medication in patients with ongoing ventricular arrhythmias, despite amiodarone and lidocaine4. Quinidine has also been used for patients as a salvage therapy for patients with structural heart disease for recurrent ventricular arrhythmias despite antiarrhythmic drug treatment 4.
- What medications can be associated with polymorphic VT?
- Medications that are commonly associated with QT prolongation, therefore making patients more susceptible to developing VT, include Class I and Class III antiarrhythmics; fluoroquinolone and macrolide antibiotics, as well as antifungals; tricyclic antidepressants as well as certain SSRI’s and SNRI’s; and antipsychotics, among others5.
- How can multimodal imaging help reach a diagnosis in patients with PMVT with a relatively normal echocardiogram and no coronary artery disease?
- Multimodal imaging, specifically cardiac MRI, is useful for reaching a diagnosis in patients with PMVT due to improved myocardial tissue characterization.
- Improved definition of the myocardium allows for the detection of structural abnormalities that may not be as easily visualized on TTE, such as LV non-compaction, now called excessive trabeculation of the left ventricle, and to more accurately measure left ventricular wall thickness, which is useful for diagnosing and risk stratifying patients with hypertrophic cardiomyopathy.
- Improved tissue characterization by measuring T1 relaxation time, T2 relaxation time, extracellular volume, and late gadolinium enhancement (LGE) pattern is also useful for diagnosing infiltrative disease. Certain LGE patterns are associated with different cardiac conditions and play a role in determining prognosis. For example, the detection of mid-wall LGE in patients with dilated cardiomyopathy portends an increased risk of adverse events.
- What are the risk factors for sudden cardiac death in patients with HCM?
- The updated 2024 HCM guidelines have outlined several risk factors for sudden cardiac death 1
- Family history of sudden cardiac death
- Unexplained syncope
- NSVT episodes on ambulatory monitoring when runs are frequent (≥ 3), longer (≥ 10 beats), and faster (≥ 200 bpm)
- Increased LV wall thickness, with elevated risk greater than 30 mm
- Other risk stratification markers include extensive LGE seen on cardiac MRI, apical aneurysm, and EF < 50% in patients without high-risk features 1
- The AHA HCM SCD Calculator can be used to risk stratify patients to assist with decision-making in ICD implantation in these patients2
References
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