Nemone Metaxas and the Reverend Richard Coles are joined by Simon Le Bon. As lead singer of Duran Duran: a band that has sold over 100 million records, had 18 American hit singles and 21 UK Top 20 tunes, he continues to perform to sold-out audiences around the world. He married a supermodel, had a family and explored his passion for yachts - his life the epitome of glamour. Now a proud grandfather, Simon Le Bon will be live in the studio.

We also have Ruqsana Begum, who is a Muay Thai world champion, the world’s first female Muslim boxing champion, who for five years kept her sport a secret from her family.

and Cardiff based café owner Kemi Nevins, who was fostered as a baby, her parents advertising the opportunity in the local paper. It was the start of a relationship she treasured for life.

And Andrew Cotter the sports commentator whose videos reporting on the behaviour of his dogs, Olive and Mabel, have accrued millions of views online.

We'll have the Inheritance Tracks of actor Mark Strong who chooses Mr Soft by Cockney Rebel and Birgit Nilsson singing the aria Liebestod from Wagner’s Tristan & Isolde, and your Thank you.

Producer: Corinna Jones Editor: Eleanor Garland

Episode 257: Clinical Presentation of Sickle Cell Disease