Sep 06 2024 This Week in Cardiology

Sep 6, 2024

In this engaging discussion, John Mandrola, MD, a cardiology expert, dives into recent groundbreaking clinical trials. He shares insights on the ABYSS trial, questioning the role of beta-blockers post-myocardial infarction. The conversation also touches on the SHAM-PVI trial for AFib ablation and its implications for practice. Mandrola highlights the FINEARTS HF trial, emphasizing the benefits of finerenone for heart failure with preserved ejection fraction. This episode is a treasure trove of valuable information for healthcare professionals!

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Recent Advances in Cardiological Trials and Their Implications

00:00 • 30min

Feedback on ABYSS and beta-blockers, more ESC recap, including SHAM-PVI, FINEARTS-HF, and RESHAPE HF2 trials are the topics John Mandrola, MD, discusses in today’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Feedback on ABYSS

Setbacks After Stopping Beta-Blockers

https://www.medscape.com/viewarticle/setbacks-after-stopping-beta-blockers-2024a1000fv7

Beta-Blockers Post-MI? No for Me, Even After the ABYSS Trial

https://www.medscape.com/viewarticle/beta-blockers-post-mi-no-me-even-after-abyss-trial-2024a1000fva

ABYSS trial https://www.nejm.org/doi/full/10.1056/NEJMoa2404204
REDUCE AMI https://www.nejm.org/doi/full/10.1056/NEJMoa2401479
QOL paper REDUCE AMI https://doi.org/10.1093/ehjcvp/pvae062
Atenolol ED paper 10.1016/j.ehj.2003.08.016

II. SHAM-PVI

JAMA SHAM-PVI paper https://jamanetwork.com/journals/jama/article-abstract/2823283
Gupta QOL paper https://pubmed.ncbi.nlm.nih.gov/33952593/

III. FINEARTS HF

Finerenone Benefits Heart Failure With Preserved EF

https://www.medscape.com/viewarticle/finerenone-benefits-heart-failure-preserved-ef-2024a1000fza

Topline Finerenone Results Point to Advance in Heart Failure

https://www.medscape.com/viewarticle/topline-finerenone-results-point-advance-heart-failure-2024a1000fq2

FINEHEARTS -HF NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2407107
FIDELIO-DKD https://www.nejm.org/doi/full/10.1056/NEJMoa2025845
FIGARO-DKD https://www.nejm.org/doi/full/10.1056/NEJMoa2110956
Why Have We Not Been Able to Demonstrate Reduced Mortality in Patients With HFmrEF/HFpEF? https://doi.org/10.1016/j.jacc.2024.08.033

IV. RESHAPE HF

TEER in Functional MR: Data Deluge, but No Easy Answers

https://www.medscape.com/viewarticle/teer-functional-mr-data-deluge-no-easy-answers-2024a1000fvg

Mitra FR https://www.nejm.org/doi/full/10.1056/NEJMoa1805374
COAPT https://www.nejm.org/doi/full/10.1056/NEJMoa1806640
RESHAPE- HF2 https://www.nejm.org/doi/full/10.1056/NEJMoa2314328
RESHAPE Subgroup paper https://doi.org/10.1016/j.jacc.2024.08.027

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