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The Stem Cell Podcast

Ep. 275: “Liver Organogenesis” Featuring Dr. Ludovic Vallier

Sep 3, 2024
Dr. Ludovic Vallier, a leading expert in stem cells from the Berlin Institute of Health, shares groundbreaking insights into liver organogenesis. He discusses modeling non-alcoholic fatty liver disease and how his lab transitioned to researching SARS-CoV-2 during the pandemic. Vallier explains the potential of induced pluripotent stem cells (iPSCs) for liver regeneration after injury. The conversation also sheds light on the innovative therapies being developed for liver diseases and the collaboration happening within Germany's scientific community.
01:11:31

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Quick takeaways

  • Dr. Ludovic Vallier emphasizes the importance of understanding cell fate decisions during liver organogenesis to generate essential liver cell types for therapeutic applications.
  • The podcast discusses advancements in interspecies chimerism aimed at enhancing human and non-human cell adhesion, potentially aiding organ transplantation efforts.

Deep dives

Liver Organogenesis and Research Focus

The research focuses on liver organogenesis and the cellular dynamics involved in liver development and regeneration. Dr. Ludovic Vallier emphasizes the relevance of understanding cell fate choices during liver organogenesis to generate functional cell types essential for liver health, such as hepatocytes and cholangiocytes. His lab aims to address liver diseases, particularly non-alcoholic fatty liver disease, and develop cell-based therapies as potential treatments. By utilizing pluripotent stem cells and organoid technology, the research targets both the fundamental aspects of liver biology and their translational applications in regenerative medicine.

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