NMN, NAD+ and other acronyms of anti-aging

As we age, levels of a vital molecule called nicotinamide adenine dinucleotide (NAD+) decline. Could reversing this be the key to eternal youth?

There’s huge interest in NAD-boosting supplements like nicotinamide mononucleotide (NMN). But is there good evidence that they can help us live longer, healthier?

Norman and Tegan unpack how NAD+ became the focus of anti-aging proponents.

This episode first aired on November 4, 2024.

References:

• NAD+ metabolism and its roles in cellular processes during ageing
• NAD+ in Brain Aging and Neurodegenerative Disorders
• What is really known about the effects of nicotinamide riboside supplementation in humans
• Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions
• The use of a systems approach to increase NAD+ in human participants
• Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging