NEJM AI Grand Rounds

Machines & Genes: The Future of AI in Biology with Dr. George Church

Oct 25, 2023

Vanguard geneticist Dr. George Church discusses his pioneering work in genomics and synthetic biology, including DNA sequencing and CRISPR gene editing. He shares controversial ideas about resurrecting wooly mammoths and using genome sequencing in dating apps. Dr. Church emphasizes the potential for synthetic biology and genetics to transform medicine and society, and explores the impact of AI on biology, including protein and nucleic acid design. The chapter also delves into the democratization of gene editing and AI technology and the importance of ethics and protocols.

49:48

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Episode guests

George Church

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Episode notes

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Quick takeaways

AI can revolutionize genetics by improving genetic diagnostics, personalized medicine, and interpreting genomes.

Clinicians should have a basic understanding of AI and genetics to leverage AI tools in medicine and interpret AI-based diagnostics.

Deep dives

AI and its Impact on Medical Specialties

AI has the potential to greatly impact medical specialties such as genetics and age-related diseases. In genetics, AI can play a role in interpreting genomes and polygenetic risk scores, improving genetic diagnostics and personalized medicine. In age-related diseases, AI can aid in developing multiple gene therapies and treatments, potentially extending healthy lifespan and treating a wide range of diseases associated with aging.

Introduction

2min

Fascinating Work and Ambitious Projects: A Conversation with George Church

3min

Computer Science History and Creating Cold-Resistant Elephants

8min

Genome Release, IRB Approval, and Benefits of Making Medical Records Publicly Available

3min

The Impact of AI on Biology

30min

Democratization of Gene Editing and AI Technology: Balancing Safety and Progress

4min

In this episode, vanguard geneticist Dr. George Church recounts his storied career from his early fascination with computers and science to his pioneering work in genomics and synthetic biology. Dr. Church developed innovative DNA sequencing methods that enabled the first sequencing of the human genome. He was also instrumental in developing CRISPR gene editing technology. Dr. Church discusses his controversial ideas around resurrecting wooly mammoths and using genome sequencing in dating apps to prevent genetic diseases. He also provides insights into founding genomics companies and the role of AI in advancing biotechnology. As a professor of genetics at Harvard Medical School and the founder of multiple genomics companies, Dr. Church emphasizes the potential for synthetic biology and genetics to transform medicine and society.

Transcript.