Locked On 49ers - Daily Podcast On The San Francisco 49ers

Week 11 Showdown: Can the 49ers Take Advantage of Equally Banged Up Arizona Cardinals?

6 snips
Nov 13, 2025
In a riveting discussion, hosts break down the upcoming clash between the 49ers and Cardinals. Christian McCaffrey's vital role is highlighted, alongside concerns about injuries impacting both teams. Key matchups are analyzed, such as Arizona's offensive line struggles and passing threats like Trey McBride. They explore how the 49ers might generate pass rush without stars like Nick Bosa and offer strategic keys for success, emphasizing turnovers and protecting the quarterback. Predictions reveal an expectedly competitive battle that could surprise many.
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INSIGHT

McCaffrey Is The 49ers Offensive Hub

  • Christian McCaffrey is the central playmaker in the 49ers offense, heavily used as both runner and receiver.
  • His route-running and target volume simplify the quarterback's job and keep chains moving.
INSIGHT

Injuries Level The Playing Field

  • Both teams are similarly banged up and relying on backup quarterbacks to varying degrees.
  • The 49ers have still managed to stay competitive despite injuries, aided by steady quarterback play.
INSIGHT

Quarterback Stability Wins Close Games

  • Close losses can stem from small differences like sustained drives and turnover timing.
  • A dependable quarterback who prevents turnovers can flip one-score losses into wins.
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