On this episode of 49ers Talk, Matt Maiocco and Laura Britt discuss how the 49ers should move forward and which players need to step up and fill the void left by the key injuries suffered vs. the Jets. Then, SNY NFL Insider Ralph Vacchiano stops by to preview the 49ers' Week 3 matchup against the Giants before closing the show with former 49ers linebacker and new NBC Sports Bay Area analyst Takeo Spikes.

(2:13) Garoppolo likely out against Giants

(7:15) Expectations for Mullens in Week 3

(11;13) Vacchiano explains the turf issue in MetLife Stadium

(15:25) How will Giants offense attack the injured 49ers defense?

(23:40) Can running game be successful going forward?

(29:30) Is there more pressure on the offense after injuries?

(35:11) Spikes explains how the 49ers are built for success

(42:11) Spikes reveals his expectations for the defense

(44:30) Spikes discusses Warner’s importance

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245. Takeo Spikes discusses 49ers' injuries, how team should move forward