Core IM | Internal Medicine Podcast
#133 Post-Kidney Transplant: 5 Pearls Segment
Aug 16, 2023
Topics discussed in this podcast include side effects of tacrolimus and mycophenolate, medication interactions, unique causes of acute kidney injury in transplant recipients, viral syndromes associated with fever, signs and symptoms of rejection, immunosuppression, medication reconciliation, infections in transplant patients, transplant rejection, cancer after transplant, the role of steroids in post-kidney transplant maintenance, medication management and adherence, challenges and treatment options for hydro-nephrosis, viral serologies and risk factors, and cancer screening in immunocompromised patients.
44:36
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Quick takeaways
- Side effects of tacrolimus include neurotoxicity, hypertension, and hair loss, while mycophenolate can cause bone marrow toxicity and gut toxicity.
- Medication reconciliation is crucial for transplant patients to ensure proper immunosuppressive medication adherence and adjustment based on trough levels.
Deep dives
Types of Immunosuppression and Common Side Effects
Immune suppression is necessary for kidney transplant patients to prevent rejection. Medications like tacrolymus and mycophenolate are commonly used for immune suppression. Tacrolymus and cyclosporin are part of the calcineurin inhibitor group and work by blocking the production of IL2 and T cells. Side effects of tacrolymus include neurotoxicity, hypertension, and hair loss. Mycophenolate works by stopping purine synthesis and common side effects include bone marrow toxicity and gut toxicity.
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