In this first-ever AMA episode, Dave tackles your biggest biohacking questions—straight from The Upgrade Collective! From optimizing brain power to pushing the limits of cold therapy, this episode is packed with cutting-edge hacks to supercharge your body and mind. If you’d like to have your questions answered on the next AMA, click the link below for details on The Upgrade Collective membership, and get all sorts of extra biohacking add-ons for your life!

In today’s episode: What if you could amplify oxytocin—the “love hormone”—to build stronger relationships and lower stress? Or upgrade your cold plunge routine for max benefits in less time? Dave reveals the science behind these powerful biohacks, plus his take on rapamycin for longevity, the right way to supplement for thyroid health (without a prescription), and even how he personally overcame Asperger’s traits through neuroplasticity and mitochondrial upgrades. There’s even some great advice for all the parents out there!

What You’ll Learn:

• How to naturally boost oxytocin for better relationships and emotional health

• The fastest way to upgrade your cold plunge for heat shock benefits

• Is rapamycin really a longevity miracle? Dave’s personal take

• How mitochondria impact brain power, mood, and aging—and how to fix them today!

• The shocking reason some people can’t process reality correctly (and how to retrain your brain)

• The real truth about stem cells, exosomes, and V-cells for regeneration

• The hidden dangers of selenium, thyroid supplements, and over-fasting

SPONSORS

-Puori | Visit https://puori.com/dave and use code DAVE for 20% storewide.

-Calroy | Head to https://calroy.com/dave for an exclusive discount.

Resources:

• Upgrade Collective Membership: https://www.ourupgradecollective.com

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• 2025 Biohacking Conference: https://biohackingconference.com/2025

• Danger Coffee: https://dangercoffee.com

• Dave Asprey’s Website: https://daveasprey.com

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey

• Own an Upgrade Labs: https://ownanupgradelabs.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com

Timestamps:

• 00:00 – Intro

• 00:37 – Welcome to the Human Upgrade AMA

• 01:13 – Cold Plunges and Alpha Lipoic Acid for Health

• 03:11 – Hot and Cold Therapy for Optimal Health

• 07:29 – Understanding Thyroid Health and Treatment

• 09:09 – The Importance of Selenium

• 14:41 – Stem Cells vs. Exosomes

• 16:27 – Rapamycin for Longevity

• 18:07 – Asperger’s Syndrome and Neuroinflammation

• 28:53 – Understanding Asperger’s and Self-Awareness

• 29:24 – The Challenge of Offering Help

• 30:06 – The Importance of Reconnection Work

• 31:34 – Personal Development Journey

• 34:42 – The Role of Emotions in Biohacking

• 35:55 – Dealing with Flashbacks and Trauma

• 45:46 – The Power of Oxytocin

• 49:48 – The Truth About Kale and Oxalates

• 54:25 – Teaching Kids to Regulate Their Nervous System

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