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ESC TV Today – Your Cardiovascular News
Season 2 - Ep. 6: All you need to know about Lp(a) - Chronic total coronary occlusions
Dec 7, 2023
Cardiology experts Carlos Aguiar and Carlo di Mario discuss Lp(a) and chronic total coronary occlusions. They explore the risks and treatments of LP Little A and the importance of chronic total occlusion of coronary arteries. Guest Lale Tokgozoglu explains the role and limitations of the P-value in clinical studies.
20:53
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Quick takeaways
- High levels of LP Little A are associated with increased risks of cardiovascular events, and targeted therapies show promise in reducing LP Little A levels.
- Symptomatic benefit is seen in patients with chronic total occlusion (CTO) of coronary arteries, and ongoing technical developments may improve CTO revascularization outcomes.
Deep dives
The Relevance of LP Little A and Its Contribution to Cardiovascular Disease
LP Little A is a prevalent and causal risk factor for atherosclerotic vascular disease. It consists of an LDL-like particle that carries cholesterol into the arterial walls. High levels of LP Little A are associated with increased risks of myocardial infarction, aortic stenosis, heart failure, ischemic stroke, and cardiovascular mortality. Recurrent cardiovascular events may indicate elevated LP Little A levels. Lifestyle interventions have minimal impact on LP Little A levels, which are mostly determined by genetic variability. LP Little A should be measured at least once in individuals' lifetimes and in patients with less than expected reductions in LDL cholesterol or recurrent events despite lipid-lowering therapy. While therapeutic options are currently limited, specific therapies under investigation show promising reductions in LP Little A levels.
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Discover
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