MCAT Basics (from MedSchoolCoach) Metabolism: Glycolysis, Krebs Cycle, Electron Transport Chain
Oct 31, 2024
Dive into the fascinating world of metabolism with a detailed exploration of glycolysis, the Krebs cycle, and the electron transport chain. Unravel the key enzymes and regulation points in glycolysis. Discover how the citric acid cycle drives energy production and the roles of pivotal intermediates. Gain insights into the electron transport chain's function and the creation of ATP through proton gradients. Mnemonics and practical tips for mastering these concepts make it a must-listen for anyone prepping for the MCAT.
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Simplify Glycolysis Steps
- Simplify glycolysis by remembering key transformations: phosphorylation, isomerization, cleavage, and pyruvate formation.
- Use this streamlined view to identify enzymes and intermediates in MCAT questions efficiently.
Memorize Glycolysis Rate-Limiting Enzymes
- Memorize the rate-limiting irreversible enzymes: hexokinase/glucokinase, phosphofructokinase, and pyruvate kinase.
- Use the mnemonic HGPFPK to recall these key glycolysis enzymes on the MCAT.
Key Glycolysis Regulation Points
- Know glycolysis regulation: ATP and citrate inhibit phosphofructokinase while AMP and fructose 2,6-bisphosphate activate it.
- Recognize hexokinase is inhibited by glucose 6-phosphate and pyruvate kinase is regulated by ATP and fructose 1,6-bisphosphate.