TWiV 1208: Clinical update with Dr. Daniel Griffin

14 snips

Apr 12, 2025

In this discussion, Dr. Daniel Griffin, a physician and infectious disease researcher, highlights critical developments in public health. He expresses concerns about the resurgence of measles and pertussis, linking it to declining vaccination rates amid misinformation. Dr. Griffin also covers the implications of the herpes zoster vaccine on dementia risk and discusses the effects of long COVID—including brain volume impacts and treatment options. His insights underscore the importance of vaccinations and informed health choices.

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INSIGHT

Dementia Vaccine?

A new study suggests a potential vaccine against dementia, using the herpes zoster vaccine.
This builds on research implicating neurotropic herpes viruses in dementia development.

ANECDOTE

Measles Deaths and RFK Jr.'s Actions

Two children have died in a Texas measles outbreak, prompting calls for stronger vaccine endorsements.
RFK Jr., while publicly supporting vaccination, privately undermines vaccine confidence.

ADVICE

Measles Vaccination Crucial

Get the MMR vaccine; it's safe and effective and does not cause autism.
Unvaccinated children become unvaccinated adults, vulnerable to preventable diseases.

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In his weekly clinical update, Dr. Griffin with Vincent Racaniello mourn the demise of vaccination against childhood diseases when discussing the continuing measles outbreak and the rise of pertussis, the first human case of H5N1 in Mexico, and human metapneumovirus before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections and vaccination schedules, the WasterwaterScan dashboard, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, long COVID interventions, if antiviral therapy prevents long COVID and how long COVID may affect brain volume.

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Links for this episode

A natural experiment on the effect of herpes zoster vaccination on dementia (Nature)
Taking a shot at dementia (microbeTV: TWiV)
RFK Jr. visits Texas after second child dies of measles amid outbreak (Washington Post)
Kennedy Attends Funeral of Texas Girl Who Died of Measles(NY Times)
‘Most effective way’ to prevent measles is vaccination, RFK Jr. says, in most direct remarks yet (STAT News)
Fort Bliss…..Fort measles: Beaumont Army hospital confirms measles case at Fort Bliss(KTSM News)
Measles cases and outbreaks (CDC Rubeola)
Measles 159 in Texas…. (Texas Health and Human Services)
Measles vaccine recommendations from NYP (jpg)
2025 Measles outbreak guidance (New Mexico Health)
Get the FACTS about measles (NY State Department of Health)
Measles (CDC Measles (Rubeola))
Measles vaccine (CDC Measles (Rubeola)
Presumptive evidence of measles immunity (CDC)
Contraindications and precautions to measles vaccination (CDC)
Measles (CDC Measles (Rubeola))
Doctors’ talk measles (YouTube)
Measles (CDC: Measles Rubeola)
Adverse events associated with childhood vaccines: evidence bearing on causality (NLM)
Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America)
Deaths following vaccination: what does the evidence show (Vaccine)
Two infants die of whooping cough in Louisiana (CNN)
Clinical features of pertussis (CDC: Whooping cough Pertussis)
Pertussis vaccination recommendations (CDC: Whooping cough Pertussis)
Diphtheria vaccination (CDC: Diphtheria)
Mexico’s first human case of H5N1 (Reuters)
Human metapneumovirus seasonality and co-circulation with respiratory syncytial virus — United States, 2014–2024 (CDC: MMWR)
Influenza: Wastewater scan for 11 pathogens (WastewaterSCan)
US respiratory virus activity (CDC Respiratory Illnesses)
Weekly surveillance report: clift notes (CDC FluView)
Respiratory virus activity levels (CDC Respiratory Illnesses)
FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA)
RSV: Waste water scan for 11 pathogens (WastewaterSCan)
US respiratory virus activity (CDC Respiratory Illnesses)
RSV-Network (CDC Respiratory Syncytial virus Infection)
Waste water scan for 11 pathogens (WastewaterSCan)
COVID-19 deaths (CDC)
COVID-19 national and regional trends (CDC)
COVID-19 variant tracker (CDC)
SARS-CoV-2 genomes galore (Nextstrain)
Human source SARS-CoV-2 aerosol transmission to remote sentinel hamsters (OFID)
Interim clinical considerations for use of COVID-19 vaccines in the United States (CDC Vaccines & Immunizations)
Where to get pemgarda (Pemgarda)
EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
Fusion center (Prime Fusions)
CDC Quarantine guidelines (CDC)
NIH COVID-19 treatment guidelines (NIH)
Drug interaction checker (University of Liverpool)
Infectious Disease Society guidelines for treatment and management (ID Society)
Cost-effectiveness analysis of nirmatrelvir/ritonavir for high-risk individuals with COVID-19….does this mean use the big button calculator? (OFID)
Molnupiravir safety and efficacy (JMV)
Convalescent plasma recommendation for immunocompromised (ID Society)
What to do when sick with a respiratory virus (CDC)
When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
Managing healthcare staffing shortages (CDC)
Steroids, dexamethasone at the right time (OFID)
Anticoagulation guidelines (hematology.org)
Daniel Griffin’s evidence based medical practices for long COVID (OFID)
Long COVID hotline (Columbia : Columbia University Irving Medical Center)
The answers: Long COVID
Nirmatrelvir–ritonavir versus placebo–ritonavir in individuals with long COVID in the USA (PAX LC): (LANCET: Infectious Diseases)
Quantitative brain volume differences between COVID-19 patients and non-COVID-19 volunteers (NeuroImage)
Donepezil for fatigue and psychological symptoms in post–covid-19 condition (JAMA Network Open)
Letters read on TWiV 1208
Dr. Griffin’s COVID treatment summary (pdf)
Timestamps by Jolene Ramsey. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Content in this podcast should not be construed as medical advice.