ICU Primary PrepCast #Epi 93 - ICU Primary Snippet 36 - Fibrinolysis and Alteplase
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Sep 22, 2024 Dive into the fascinating world of fibrinolysis and its crucial role in the coagulation cascade. Discover how plasmin and tissue plasminogen activator (TPA) work together to dissolve blood clots. The discussion highlights the importance of alteplase as a key therapeutic agent while also addressing possible adverse effects. It's a deep dive into mechanisms that can save lives, wrapped up in engaging insights!
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Fibrinolysis Inhibitors
- Inhibitors like plasminogen activator inhibitor 1 & 2, TAFI, and alpha-2 antiplasmin regulate fibrinolysis.
- These inhibitors prevent excessive plasmin activity and maintain a balance with clot formation.
TPA's Role
- Tissue plasminogen activator (TPA) is released by injured endothelial cells.
- TPA activates plasminogen bound to fibrin, initiating localized clot degradation.
Fibrinolysis Overview
- Fibrinolysis, the clot breakdown process, uses proteolytic enzymes to regulate clot formation.
- Plasmin, produced from plasminogen, is the key enzyme, cleaving fibrin into degradation products.