In this podcast, the hosts discuss RSV immunizations with Dr. Buddy Creech. They explore the challenges and solutions of RSV immunizations and the differences between adjuvanted and non-adjuvanted vaccines. The chapter also covers the adverse effects and safety considerations of RSV vaccines, including its co-administration with flu vaccines. Lastly, they discuss the importance of eradicating RSV globally and providing high-value practice-changing knowledge.
Vaccination against RSV is available for both infants and adults, with Bayfortis recommended for infants and AretaSub and AbrezaSub suitable for adults, offering protection against RSV symptoms and reducing hospitalizations.
RSV vaccination aims to prevent lower respiratory tract infections, reduce the burden of the disease, and may have the potential for broader coverage and expanding target populations in the future.
Deep dives
RSV Immunizations for Young and Old
RSV is a significant respiratory illness that affects both young infants and older adults. Vaccination against RSV can help prevent the disease and reduce its burden. Bayfortis (Nirsevumab) is a passive immunization option for babies that offers protection against RSV. For older individuals, there are two active immunization options: AretaSub and AbrezaSub vaccines. Both vaccines target the pre-fusion confirmation of the F protein of RSV and have demonstrated efficacy in reducing symptoms and hospitalizations related to RSV. The vaccines have different adjuvant options, and while they may cause some local and systemic side effects, the benefits of preventing RSV outweigh the risks. These vaccines serve not only to protect individuals but also to reduce the overall burden of RSV in the community. Pregnant women can receive the Pfizer vaccine to provide passive protection to their babies. Ongoing studies will further explore the effectiveness and long-term impact of RSV vaccines.
Considerations for Vaccination
When considering RSV vaccination, it is important to distinguish between the different vaccines available and their target populations. Bayfortis is recommended for infants, while AretaSub and AbrezaSub are suitable for adults. Both Pfizer and GSK vaccines have shown efficacy in reducing RSV symptoms, with the Pfizer vaccine offering protection during pregnancy to benefit newborns. Adjuvanted vaccines may have slightly different side effects compared to non-adjuvanted vaccines, but the overall risks are minimal. Close monitoring of any potential adverse events is ongoing. It is crucial to understand that RSV vaccination aims to prevent lower respiratory tract infections and reduce the burden of the disease, which can lead to future complications such as asthma.
Future Perspectives
As RSV vaccines continue to be developed, there is a potential for broader coverage and expanding the populations eligible for vaccination. Pregnant women and infants are currently the main target groups for vaccination, but ongoing research may reveal additional groups that can benefit. The goal is to reduce the overall burden of RSV and other respiratory viral infections by including them in routine vaccination strategies. By doing so, we can safeguard the health of individuals and achieve better public health outcomes. Continued surveillance and research will shape the future of RSV vaccination.
The Curbsiders and Cribsiders are back with a very special Med-Peds collaboration on RSV immunizations! Dr. Buddy Creech, Pediatric Infectious Disease at Vanderbilt, walks us through these breakthrough “vaccines" for both adults and kids. He teaches us about their mechanisms of action, eligibility criteria, and why it’s been so challenging to find doses this season. Get ready for your next shot of fun!
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