The Cribsiders S5 Ep102: RSV Immunizations
Jan 31, 2024
In this podcast, the hosts discuss RSV immunizations with Dr. Buddy Creech. They explore the challenges and solutions of RSV immunizations and the differences between adjuvanted and non-adjuvanted vaccines. The chapter also covers the adverse effects and safety considerations of RSV vaccines, including its co-administration with flu vaccines. Lastly, they discuss the importance of eradicating RSV globally and providing high-value practice-changing knowledge.
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RSV's U-Shaped Risk Curve
- RSV causes significant illness especially at age extremes: infants and older adults.
- It is a leading cause of hospitalization, similar to influenza in risk patterns.
Nirsevimab for Infant RSV Protection
- Use Nirsevimab (Bayfortis) for passive RSV immunization in infants under eight months or with risk factors.
- Emphasize correct immunization use and avoid giving adult RSV vaccines to infants.
Targeting RSV Pre-Fusion Protein
- RSV F protein's pre-fusion form is the optimal vaccine target to block virus entry to cells.
- Binding pre-fusion prevents infection initiation better than targeting post-fusion forms.