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The Drug Discovery World Podcast

DDW Highlights: 2 September 2024

Sep 2, 2024
Dive into groundbreaking advancements in drug discovery! Discover the international clinical trial exploring BioNTech’s mRNA lung cancer vaccine. Learn about innovative treatments making waves, including a monoclonal antibody and a new GLP-1 agonist for obesity. Plus, insights on a selective agonist for schizophrenia that could change lives. Join the buzz around these exciting clinical trials and the future of healthcare!
10:13

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Quick takeaways

  • Sky Bioscience's Phase 2 clinical trial for nimasumab aims to provide safer weight loss solutions by targeting peripheral CB1 inhibition.
  • The mRNA cancer vaccine BNT116 represents a significant advance in lung cancer treatment, training the immune system for better tumor recognition.

Deep dives

Innovative Approaches in Weight Loss Therapy

Sky Bioscience is conducting a Phase 2 clinical trial for a new weight loss therapeutic, nimasumab, which targets peripheral CB1 inhibition. This trial aims to assess its safety and efficacy in reducing weight for patients with obesity while considering additional health outcomes such as gastrointestinal tolerability and muscle retention. It involves enrolling 120 patients across four treatment groups to evaluate the drug's effects compared to a placebo and GLP-1 based treatments. The trial's design reflects a growing need for alternative weight loss solutions that provide better overall health results and sustainability beyond traditional therapies.

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