Science Quickly The Role Our Microbiome Plays In Our ‘Gut Feelings’
Sep 17, 2025
In this engaging discussion, guest Maya Kaelberer, an assistant professor at the University of Arizona, reveals how our gut microbiome influences our emotions and cravings. She explains the surprising communication between intestinal cells and the brain, highlighting its impact on mental health and dietary choices. Maya also dives into fascinating research about neuropod cells and their role in shaping our food preferences. This episode offers intriguing insights into how our gut feelings can dictate our happiness and wellness.
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Gut Cells Signal Directly To The Brain
- Specialized intestinal cells can send direct signals to the brain that shape appetite and mood.
- This gut-to-brain wiring provides a biological basis for everyday “gut feelings.”
Personal Coffee Preference Explains Research
- Maya Kaelberer shares a personal food preference to illustrate gut sensing: she prefers artificial sweetener to regular sugar.
- She connects that preference to neuropod cells distinguishing sugar versus sweetener signals and influencing consumption.
Microbes Use A Tail Protein To Influence Feeding
- Neuropod cells sense a bacterial tail protein (flagellin) and relay information that reduces feeding when present.
- This creates a direct circuit through which the microbiome communicates host food needs.