Oncology Brothers: Practice-Changing Cancer Discussions Clinical Implications of Testing HER2 and Targeted Therapies Approved - Dr. Komal Jhaveri
In this episode of the Oncology Brothers podcast, we are joined by Dr. Komal Jhaveri, a breast medical oncologist at Memorial Sloan Kettering, to discuss the evolving landscape of metastatic hormone receptor positive breast cancer, particularly focusing on low and ultra-low HER2 expression.
Key topics include:
• The significance of the DESTINY Breast-04 and DESTINY Breast-06 studies and their impact on treatment options.
• The definition and implications of low and ultra-low HER2 expression in clinical practice.
• The importance of HER2 testing and the dynamic nature of HER2 expression in tumors.
• Treatment sequencing strategies, including the use of antibody-drug conjugates (ADCs) like trastuzumab deruxtecan (TDXd) and sasituzumab govitecan.
• Management of treatment-related toxicities, including ILD, nausea, and alopecia.
Join us for an insightful discussion that aims to keep healthcare professionals updated on the latest advancements in cancer care.
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