This Week in Cardiology Oct 17 2025 This Week in Cardiology
8 snips
Oct 17, 2025 Discover the latest insights into anticoagulation therapies as new findings show the risks of combining antiplatelets with anticoagulants. Explore the potential of a multi-drug polypill for heart failure and the practical challenges it poses. Hear about the future of physical exams and how point-of-care ultrasound could revolutionize assessments. John also delves into underpowered trials and the implications of uncertain results, urging caution in changing clinical practices.
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Skip Heparin For New Atrial Fibrillation
- Avoid routine use of heparin/LMWH for acute AF; start a DOAC the first day instead.
- John Mandrola argues subcutaneous or IV heparin for new AF is non–evidence-based and slows thinking.
Listener Note On GLP‑1s And SGLT2s
- John received feedback that prior GLP-1 HF studies predated common SGLT2 use and that combined therapy might differ.
- He remains skeptical but acknowledges weight loss from GLP-1 could benefit selected ischemic cardiomyopathy patients.
PFA Hemolysis Varies By Context
- John shares peer feedback about PFA causing dose-related hemolysis in extended posterior wall ablations.
- He notes their center's experience with a different PFA system showed no hemolysis in >300 cases.
