Explore the complexity of Chronic Spontaneous Urticaria, treatment options like Omalizumab, advancements in medications like Remibrutinib and Barzdol Volimap, and the link between urticaria and mental health in this insightful podcast by Lara and Vyanka.
Chronic spontaneous urticaria is characterized by continuous allergic cells' contents release causing itchy swellings on the skin.
Understanding the distinctions between chronic spontaneous and chronic-inducible urticaria aids in accurate diagnosis and treatment.
Deep dives
Understanding Urticaria and its Types
Urticaria, characterized by itchy wheels that disappear and reappear on the body, comes in two forms - acute and chronic. Acute Urticaria lasts less than six weeks and is common, affecting about one in five people, while chronic Urticaria, lasting longer than six weeks, is rare and seen in about one in four Acute Urticaria patients. Chronic spontaneous Urticaria, a subtype of chronic Urticaria, constitutes about 75% of cases and is associated with angioedema, a deeper swelling that's non-itchy and takes longer to disappear.
Explanation of Chronic Spontaneous Urticaria and Angioedema
Chronic spontaneous Urticaria, the primary subtype of chronic Urticaria, is linked to the continuous release of allergic cells' contents, causing itchy swellings on the skin. In contrast, chronic-inducible Urticaria is triggered by factors like cold or pressure leading to sudden Urticarial wheels. Angioedema, deeper swellings not involving itchiness, can occur alongside Urticaria but takes longer to disappear. Understanding these distinctions helps in accurate diagnosis and treatment.
Managing Chronic Spontaneous Urticaria
Around half of Chronic Urticaria patients can be effectively managed by primary care physicians without extensive testing. The recommended treatment involves non-sedating antihistamines taken daily, with adjustments in dosage if needed. Guidelines like the iaki protocol outline steps to reassure patients, conduct appropriate lab work, and provide relief. For patients unresponsive to standard treatments, options like Omalizumab injections and, in rare cases, cyclosporine may be considered.
Future Treatment and Research Developments in Urticaria
Exciting advancements in Urticaria treatment include new medications like Remebrootinib, Barzda Vollimap, and Lirenthalumap, showing promise for cases resistant to standard therapies. Researchers are exploring endotypes and biomarkers to tailor treatments better and understand disease mechanisms. Collaboration among Urticaria centers globally, like the UKER network, fosters knowledge exchange and paves the way for improved chronic spontaneous Urticaria management.
On this episode Lara and Vyanka talk to Prof Emek Kocatürk all about chronic spontaneous urticaria. This is ImmunoTea: Your Immunology Podcast, presented by Dr Lara Dungan and Dr Vyanka Redenbaugh. This is the show where we tell you all about the most exciting research going on in the world of immunology. So grab a cup of tea, sit down and relax and we'll fill you in. Contact us at ImmunoTeaPodcast@gmail.com or @ImmunoTea on twitter.