Cryosphere Podcast Michael Benjamin - Intriguing Outcomes of Alcor's Meta-Analysis
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Jun 14, 2023 
Michael Benjamin, a seasoned physicist and engineer with nearly two decades in the industry, dives into the fascinating world of cryopreservation. He shares his experiences at NASA and the challenges posed by his health condition, scleroderma. The discussion focuses on his groundbreaking meta-analysis of Alcor's case history. Key topics include the innovative S-Mix score for evaluating cryopreservation, the impact of unattended deaths, and the ambitious initiatives of Biostasis Technologies to improve standards and training in the field.
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Historical Data Quality Varies Greatly
- Michael Benjamin found case reports varied wildly in quality and many early records were paper-based and inconsistent.
- He emphasizes that improved data collection is essential before strong conclusions about progress can be drawn.
Make Nasopharyngeal Temperature Logging A Priority
- Always record robust temperature data, prioritizing nasopharyngeal probes when choices must be made.
- Design redundant logging and clear insertion protocols to avoid missing critical cooling data.
S‑Mix Measures Ischemic Exposure, Not Direct Damage
- The S‑Mix (ESMIC) quantifies ischemic exposure by combining time and temperature during stabilization phases.
- Temperature logging is the dominant input and gaps in temperature data limit S‑Mix accuracy.