The Rest Is History 146. Disease vs. the rise of civilisation
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Feb 3, 2022 
In this discussion, guest Kyle Harper, a Professor of Classics and disease historian, explores how humanity’s relationship with infectious diseases has evolved. He reveals that for most generations, death from disease was expected, but technological advancements and globalization shifted this norm. Harper delves into the demographic dynamics of pre-modern cities, the historical impact of the Black Death, and the transition from infectious to chronic illnesses. He also highlights how these changes have shaped societal structures and urban health over time.
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Shift in Leading Causes of Death
- In the late 19th century, non-infectious diseases became the leading cause of death in the US and Britain.
- This marked a significant shift in human history, as infectious diseases had been the primary killer for most of our existence.
Infectious Diseases as the Historical Norm
- For thousands of generations, infectious diseases were the biggest fear and killer of humans.
- Only in the last few generations have we become largely insulated from this threat, making our experience anomalous.
Pathogens and Human History
- Humanity's relationship with pathogens is intertwined with the history of everything, from migration to poverty and progress.
- Humans have a broader range of pathogens than other primates due to our unique history and technological development.
